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BackgroundSpinal microglia activation is one of the pathologic mechanisms involved in post‐operative pain, which results from surgical injuries in skin, fascia, muscle and small nerves innervating these tissues. Recent research has shown that neuregulin‐1 (NRG1) and its receptor erythroblastosis oncogene B (ErbB) family mediate microglia proliferation and chemotaxis contributing to the development...
BackgroundStudies have suggested that 5‐hydroxytryptamine‐3A (5‐HT‐3A) receptor antagonists may have analgesic effects. This randomized, double‐blind, placebo‐controlled, factorial study tested the hypothesis that 5‐HT‐3A receptor antagonist tropisetron attenuates post‐operative pain in women receiving either sevoflurane or propofol based anaesthesia.
MethodsTwo hundred and ninety‐six women undergoing...
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