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Various transcription factors are also known to enhance or suppress T helper type 17 (Th17) differentiation. We have shown previously that the development of collagen‐induced arthritis was suppressed in T‐bet transgenic (T‐bet Tg) mice, and T‐bet seemed to suppress Th17 differentiation through an interferon (IFN)‐γ‐independent pathway, although the precise mechanism remains to be clarified. The present...
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