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Phosphoserine phosphatase (EC 3.1.1.3) catalyzes the final step in the major pathway of l-serine biosynthesis in brain. This enzyme may also regulate the levels of glycine and d-serine, the known and putative co-agonists for the glycine site of the N-methyl-d-aspartate receptor in caudal and rostral brain regions, respectively. Using l-phosphoserine as substrate, the rank order potency for inhibition...
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