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In heroin overdose deaths the blood morphine concentration varies substantially. To explore possible pharmacokinetic explanations for variable sensitivity to opiate toxicity we studied mortality and drug concentrations in male Sprague-Dawley rats. Groups of rats were injected intravenously (i.v.) with heroin, 21.5mg/kg, or morphine, 223mg/kg, causing a 60–80% mortality among drug-naïve rats. Additional...
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