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The objective of this study was to determine the role of histone deacetylases (HDACs) in regulating HIF‐1α protein stability and activity in nucleus pulposus (NP) cells. Treatment of NP cells with pan‐HDAC inhibitor TSA resulted in decreased HIF‐1α levels under both normoxia and hypoxia in a dose‐dependent fashion. TSA‐mediated HIF‐1α degradation was rescued by concomitant inhibition of not only the...
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