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The involvement of protein kinase C in long-term potentiation was investigated in the mossy fiber-CA3 pathway in anin vitro slice preparation of rat hippocampus. Tetanic stimulation induced stable long-term potentiation in the mossy fiber-CA3 pathway which was not affected byN-methyl-d-aspartate receptor antagonists. Long-term potentiation was not induced in the presence of a protein kinase C inhibitor,...
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