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BackgroundAutosomal recessive congenital ichthyoses (ARCIs) are keratinization disorders caused by impaired skin barrier function. Mutations in the genes encoding the lipoxygenases 12R‐LOX and eLOX‐3 are the second most common cause of ARCIs. In recent years, human skin equivalents recapitulating the ARCI phenotype have been established.
ObjectivesTo develop a murine organotypic tissue culture model...
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