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This study sought to determine if pretreatment with low-dose tumor necrosis factor-α (TNF-α) can enhance the effects of radiation in an NCI-H441 human lung tumor xenograft model. In vitro assays were performed on spleen cells, blood leukocytes, and plasma from the animals, as well as on cultured tumor cells. Tumors in animals given only TNF-α grew as well as, or better than, tumors in their untreated...
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