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To clarify if pentoxifylline (PTX) may have therapeutic potential for human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM), we investigated the in vitro effect of PTX on spontaneous proliferation of peripheral blood lymphocytes (SPP), as well as on the expression of adhesion molecules, such as lymphocyte function antigen-1 (LFA-1) and very late activation antigen-4 (VLA-4),...
A new oral agent, Pioglitazone has been developed for the treatment of NIDDM. In the present study, we administered Pioglitazone to rabbits with hypercholesterolemia, in order to determine its effects on serum lipids and atherosclerosis. Methods: Male Japan White rabbits (2.5 Kg) were used. The animals were fed with diet containing 0.5% cholesterol (group HC) or 0.5% cholesterol and 300 p.p.m. Pioglitazone...
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