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Multidrug resistance is a generic term for the variety of strategies that tumor cells develop to evade the cytotoxic effects of anticancer drugs. It is characterized by decreased cellular sensitivity, not only to the drug(s) employed in chemotherapy but also to a broad spectrum of drugs with neither obvious common targets nor structural homology. It is one of the major obstacles to the successful...
Oligosaccharides, complex carbohydrates that comprise 2-30 monosaccharides linked by glycosidic bonds, are being developed as therapeutic agents for a variety of indications. The large-scale production of oligosaccharides achieved by enzymatic synthesis has encouraged the preclinical and clinical evaluation of these carbohydrates for efficacy in infectious and inflammatory diseases, transplantation,...
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