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Summary Mechanical loading at high frequency affects bone. Whether this also applies to osteoporotic bone, combined or not with bisphosphonate therapy, was investigated in this animal study through imaging. An anabolic effect of high-frequency loading on osteoporotic bone, however non-synergistic with bisphosphonates, was found, thereby revealing its potential for treatment of osteoporosis. Introduction...
Mechanical stress plays an essential role in bone homeostasis by regulationg both bone formation and resorption. We have previously shown that cyclic stretch loading to MC3T3-E1 cells induced the expression of two bone remodeling related genes, Fn14 and MCP-3, through activation of ASK1 (a MAPKKK)/JNK and ASK1/p38 pathways, respectively. Here we show that cyclic stretch loading also induced the activation...
Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. We previously investigated the effects of loading of cyclic mechanical stretch on the activaties of JNK and p38 in MC3T3-E1 osteoblastic cells, and observed that JNK and p38 were activated by the mechanical stress. The patterns...
Although mechanical stress has been shown to regulate bone modeling and remodeling, the mechanisms of bone remodeling after mechanical stress loading are not fully understood. In this study we determined the effects of cyclic mechanical stretch of varying magnitudes and durations on the activation of JNK and p38 in MC3T3-E1 cells. Phosphorylation of both JNK and p38 was observed 5 min after the onset...
Cell function to form bone would be influenced by local environment, such as mechanical stress and tissue fluid constituents over intracellular signal transduction to macroscopic order. For example, osteoblasts and osteocytes respond to mechanical stimuli by changing their metabolism, proliferation, and differentiation. Our recent study showed that the elevated extracellular calcium stimulated secretion...
Automatic immediate fitting socket (AIFS) system was developed to shorten the long length of time for making an artificial leg, by applying powder technology. AIFS is constructed of an outer shell, a particle containing bag, which the rigidity can be controlled by the application of negative air pressure and three airbags between the outer shell and the particle bag to adjust the shape by controlling...
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