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Abstract Mast cells play an important role in the pathological development of many inflammatory and allergic diseases and inhibition of mast cell activation is a potential target for therapeutic intervention. Therefore, the effect of the novel ascomycin macrolactam derivative SDZ ASM 981 on FcRI-mediated activation of rat basophilic leukemia (RBL) cells, as a model for mast cell activation, was investigated...
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