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BACKGROUNDEarly identification of mutations may guide patients with metastatic colorectal cancer toward targeted therapies that may be life prolonging. The authors assessed tumor genotype correlations with clinical characteristics to determine whether mutational profiling can account for clinical similarities, differences, and outcomes.
METHODSUnder Institutional Review Board approval, 222 patients...
The use of neoadjuvant strategies for patients with hepatic-limited metastatic colorectal cancer has demonstrated promise for improving the outcomes of these patients. However, the potential toxicities of this strategy, along with concern for missing a critical window of resectability raise concern for clinicians and patients. Although currently few biomarkers are available for patients with metastatic...
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