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Background: The role of I Ks in the human atrium is unclear. Therefore, the effect of Chromanol 293 B (Chrom), a recently described highly selective I Ks blocker in guinea pig ventricular myocytes, was investigated in human atrial myocytes.Methods: Specimens of human atrial appendages were obtained from patients undergoing coronary bypass surgery. Patients had stable sinus...
Background: Recently, chromanol 293B (chrom) was described as a highly selective I Ks blocker in guinea pig ventricular myocytes. The objektive of the present study was to investigate the kinetics of the I Ks blockade.Methods: Freshly isolated ventricular myocytes of guinea pigs were studied with whole cell patch clamp techniques.Results: Chrom (10 μM) induced a rate-independent...
The use of a 64-polar basket catheter (B) (Constellation catheter, EPT) allows multipolar threedimensional recording of atrial tachyarrhythmias in the clinical electrophysiologic laboratory. Thus the intraatrial activation sequence can be demonstrated.Methods: We developed a software for the automatic analysis of the activation sequence. The B was used in the right atrium in 36 pts with atrial tachyarrhythmias:...
Background: Reduced action potential (AP) prolongation of currently used class III antiarrhythmics in the presence of β-adrenergic activation is supposed to be a major disadvantage of this drugs. In particular, I Kr blockade as principle mechanism of class III antiarrhythmic action was supposed to be the reason for this disadvantage, since other depolarising currents, especially I ...
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