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Aggregation of tau is a hallmark of many neurodegenerative diseases, and tau imaging with positron emission tomography (PET) may allow early diagnosis and treatment monitoring. We assessed binding of the PET tracer [18F]AV-1451 in a range of dementias.Phosphorimaging was used to quantify binding to postmortem brain tissue from 33 patients with different, histopathologically characterized, neurodegenerative...
Neural networks provide candidate substrates for the spread of proteinopathies causing neurodegeneration, and emerging data suggest that macroscopic signatures of network disintegration differentiate diseases. However, how do protein abnormalities produce network signatures? The answer may lie with ‘molecular nexopathies’: specific, coherent conjunctions of pathogenic protein and intrinsic network...
The neurodegenerative disorders all share a broad common mechanism: accumulation of abnormal protein within the nervous system leads to excess neuronal loss. Alzheimer's disease (AD), the prototypic neurodegenerative disease, is associated with accumulation of amyloid plaques and neurofibrillary tangles composed of phosphorylated tau which preceded excess neuronal loss within specific brain regions,...
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