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Progesterone (PROG) provides neuroprotection to the injured central and peripheral nervous system. These effects may be due to regulation of myelin synthesis in glial cells and also to direct actions on neuronal function. Recent studies point to neurotrophins as possible mediators of hormone action. Here, we show that the expression of brain-derived neurotrophic factor (BDNF) at both the mRNA and...
In adult male rats, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD) expressing cells were identified in the spinal cord from the cervical to the sacral segments. An in situ hybridization study, using an oligonucleotide common to the four known isoforms of rat 3β-HSD, revealed its mRNA in gray matter. Measurements of optical densities in autoradiograms showed the following regional distribution:...
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