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Objective
Colchicine is known to reduce inflammation and improve endothelial cell function and atherosclerosis in obesity, but there is little knowledge of the specific circulating leukocyte populations that are modulated by colchicine.
Methods
A secondary analysis of a double‐blind randomized controlled trial of colchicine 0.6 mg or placebo twice daily for 3 months on circulating leukocyte populations...
Objective
The aim of this study was to examine whether colchicine’s anti‐inflammatory effects would improve measures of lipolysis and distribution of leukocyte populations in subcutaneous adipose tissue (SAT).
Methods
A secondary analysis was conducted for a double‐blind, randomized, placebo‐controlled pilot study in which 40 adults with obesity and metabolic syndrome (MetS) were randomized to...
Objective
This study investigates the therapeutic potential of a small molecule inhibitor of plasminogen activator inhibitor‐1 (PAI‐1), TM5441, in reversing diet‐induced obesity in mice.
Methods
Wild‐type C57BL/6J mice were fed a high‐fat high‐sugar (HFHS) diet for 8 weeks to induce obesity. After the first 8 weeks, TM5441 was added to the diet for an additional 8 weeks. In order to determine the...
Objective
Little is known about long‐term metabolic (energy expenditure) adaptation after bariatric surgery.
Methods
Resting metabolic rate under basal conditions (RMR), total daily energy expenditure (TDEE), and body composition were measured in 25 participants in the Longitudinal Assessment of Bariatric Surgery‐2.
Results
Six months after surgery, BMI (±SD) decreased (47 ± 6 kg/m2 to 37 ± 5...
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