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The neurodegenerative disorders all share a broad common mechanism: accumulation of abnormal protein within the nervous system leads to excess neuronal loss. Alzheimer's disease (AD), the prototypic neurodegenerative disease, is associated with accumulation of amyloid plaques and neurofibrillary tangles composed of phosphorylated tau which preceded excess neuronal loss within specific brain regions,...
Structural imaging using computed tomography (CT) or, ideally, magnetic resonance imaging (MRI) is recommended in the routine assessment of all patients with dementia. Traditionally imaging in this context has been used to exclude potentially treatable causes of dementia, such as tumours and subdural haematomas. Increasingly, imaging is being used to help the clinician distinguish between different...
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