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The goal was to evaluate whether melatonin (Mel) down-regulates hTERT expression induced by 17β-estradiol (E 2 ) or cadmium (Cd) in breast cancer cells. We found that: (a) Mel inhibits E 2 or Cd-induced hTERT transcription in hTERT-Luc transfected MCF-7 cells, (b) Mel significantly reduces E 2 - and Cd-mediated hTERT transactivation triggered by ERα in transfected HeLa cells,...
In order to assess whether light exposure at night influences the growth of mammary tumors, as well as the role of melatonin in this process, female rats bearing DMBA-induced mammary adenocarcinomas were exposed to different lighting environments. Animals exposed to light-at-night, especially those under a constant dim light during the darkness phase, showed: (a) significantly higher rates of tumor...
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