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Antigen‐specific T cell receptor (TCR) gene transfer via patient‐derived T cells is an attractive approach to cancer therapy, with the potential to circumvent immune regulatory networks. However, high‐affinity tumour‐specific TCR clonotypes are typically deleted from the available repertoire during thymic selection because the vast majority of targeted epitopes are derived from autologous proteins...
Aneuploidy or alteration in chromosome numbers is a characteristic feature in cancer that is generally a consequence of defective chromosome segregation during cell division. Molecular cytogenetic analyses have conferred substantial evidence with regards to the chromosomal architectures in cancer. Most importantly, the fluorescence in situ hybridization (FISH) technique that plays a leading role in...
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