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Assessments of disease progression and response to therapies in Duchenne muscular dystrophy (DMD) patients remain challenging. Current DMD patient assessments include complex physical tests and invasive procedures such as muscle biopsies, which are not suitable for young children. Defining alternative, less invasive and objective outcome measures to assess disease progression and response to therapy...
Glycan biosynthesis is the process by which glycans are built in the cells. Information about the process is available from several Web accessible databases, published papers, experimental data produced at the Complex Carbohydrates Research Center (CCRC) as well as the knowledge accumulated by the biologists working at CCRC. The principal purpose of Glyco-Vault is to support the research of glycobiologists...
A new class of nanofluidic filter array devices were designed and fabricated to perform rapid separation (both analytical and preparative) of DNA and proteins covering very broad biological size scales. By virtue of its separation efficiency, gel-free operation, ease of sample recovery and high throughput, these nanofluidic filter array devices hold great promise for an integrated biomolecule sample...
Membrane proteins organize themselves in a linear fashion where adjacent cells are attached together along the basal-lateral region. Their intensity distributions are often heterogeneous and may lack specificity. Grouping of these linear structures can aid in segmentation and quantitative representation of protein localization. However, quantitative analysis of these signals is often hindered by noise,...
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