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Insulin-like growth factor binding proteins (IGFBPs) were characterized in bovine anterior pituitary tissue, pituitary conditioned media, and serum collected during the preovulatory and early luteal phases of the estrous cycle. Effects of in vitro treatments of pituitaries with luteinizing hormone-releasing hormone (LHRH), estradiol, and progesterone on IGFBP secretion were also evaluated. Predominant...
Pax6, an evolutionarily conserved transcription factor, is expressed in the murine and zebrafish embryonic pituitary, but its role in pituitary development and endocrine function has not been described. To study the role of Pax6 in vivo, we examined Pax6 mutant mouse (SeyNeu) pituitaries. Mice homozygous for the SeyNeu mutation die at birth; therefore, we examined peptide hormone expression...
The central role of activin in the regulation of the reproductive axis remains largely unexplored. Evidence suggests that activin may play a role in controlling gonadotropin-releasing hormone (GnRH) release. We assessed potential neuroanatomical associations between activin- and GnRH-neuronal systems via examination of the distribution of activin βA-subunit and activin binding protein (follistatin)...
Inhibin/activin subunit (α, βA, and βB) immunoreactive protein localization patterns and cell type specific inhibit α-subunit mRNA expression have been examined in early-to midgestational age human fetal testes. The scarcity of available third trimester human fetal tissue has, however, prevented a complete examination throughout the gestational period and the cell specific expression of follistatin...
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