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We demonstrated controlled conversion of DNA/Ag NCs between bright and dark states and designed a new molecular probe, NCB, for homogeneous detection of nucleic acid targets. Not relying on Forster energy transfer as the fluorescence on/off switching mechanism, NCBs have the potential to reach an ultrahigh S/B ratio in molecular sensing. Since the fluorescence enhancement is caused by intrinsic nucleobases,...
Glycan biosynthesis is the process by which glycans are built in the cells. Information about the process is available from several Web accessible databases, published papers, experimental data produced at the Complex Carbohydrates Research Center (CCRC) as well as the knowledge accumulated by the biologists working at CCRC. The principal purpose of Glyco-Vault is to support the research of glycobiologists...
Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration. Further, these models have been used to estimate the ethanol infusion profile required to prescribe a specific breath ethanol concentration time course in a specific human being, providing a platform upon which other pharmacokinetic...
The understanding of drinking patterns leading to alcoholism has been hindered by an inability to unobtrusively measure ethanol consumption over periods of weeks to months in the community environment. Signal processing for an implantable ethanol MEMS bio sensor under simultaneous development is described where the sensor-signal processing system will provide a novel approach to this need. For safety...
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