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In an experimental model of liver cirrhosis, marked increases in ER proteasome content in rat livers were observed 5h after acute i.p. injection of the hepatotoxicant CCl 4 . To confirm the role of CYP2E1 in mediating protein misfolding/damage in the ER via its metabolism of CCl 4 , 293T cells stably transfected with human CYP2E1 were exposed to CCl 4 and cell ER fractions...
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