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Rationale The wake-promoting agent modafinil selectively improves neuropsychological task performance in healthy volunteers, in adults with attention deficit hyperactivity disorder (ADHD) and in schizophrenia. We examined whether modafinil induced similar effects in individuals with Huntington’s disease (HD). Materials and methods Twenty patients with genetically proven, mild HD participated in...
Introduction Levodopa-induced dyskinesia (LID) is an inevitable complication of the long-term treatment of Parkinson’s disease (PD) with levodopa. In a rat model of LID, we observed that animals of almost identical genetic but slightly different environmental backgrounds displayed a very different profile in terms of their development and severity of LID. Materials and methods We hypothesised that...
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