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G‐protein coupled receptors (GPCRs) are the largest class of membrane proteins encoded in the human genome with high pharmaceutical relevance and implications to human health. These receptors share a prevalent architecture of seven transmembrane helices followed by an intracellular, amphipathic helix 8 (H8) and a disordered C‐terminal tail (Ctail). Technological advancements have led to over 1000...
Fluorine (19F) offers several distinct advantages for biomolecular nuclear magnetic resonance spectroscopy such as no background signal, 100% natural abundance, high sensitivity, and a large chemical shift range. Exogenous cysteine‐reactive 19F‐probes have proven especially indispensable for characterizing large, challenging systems that are less amenable to other isotopic labeling strategies such...