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MicroRNAs (miRNAs) regulate the function of several immune cells, but their role in promoting CD8 + T cell immunity remains unknown. Here we report that miRNA-155 is required for CD8 + T cell responses to both virus and cancer. In the absence of miRNA-155, accumulation of effector CD8 + T cells was severely reduced during acute and chronic viral infections and control of virus...
Th17 cells have been described as short lived, but this view is at odds with their capacity to trigger protracted damage to normal and transformed tissues. We report that Th17 cells, despite displaying low expression of CD27 and other phenotypic markers of terminal differentiation, efficiently eradicated tumors and caused autoimmunity, were long lived, and maintained a core molecular signature resembling...
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