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The monocytic phagocytic system, consisting primarily of tissue macrophages of the liver and spleen, produces prostaglandin E2 (PGE2), a modulator of the septic response. Macrophages are known to internalize gadolinium chloride (GD), a lanthanide metal, which inhibits phagocytic function. Thus we studied the effect of in vivo GD on lipopolysacchride (LPS)-induced mortality and on LPS-stimuIated PGE...
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