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The role of complement regulation at the cell surface is reviewed and the desirability of being able to design exogenous therapeutic agents that function in this way is considered. An analysis of naturally occurring membrane proteins suggested that one particular type of membrane-localization mechanism (the myristoyl-electrostatic peptide switch) could be mimicked by minimization of the key molecular...
The role of complement regulation at the cell surface is reviewed and the desirability of being able to design exogenous therapeutic agents that function in this way is considered. An analysis of naturally occurring membrane proteins suggested that one particular type of membrane-localization mechanism (the myristoyl-electrostatic peptide switch) could be mimicked by minimization of the key molecular...
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