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A new manufacturing process, known as process upgrade varicella vaccine (PUVV) was developed for a refrigerated formulation of varicella vaccine and for an investigational zoster vaccine. Safety and tolerability of a two-dose regimen of high-titered (∼50,000PFU) PUVV were compared to a lower-titer formulation (∼5400PFU) of VARIVAX™; in 1366 healthy subjects ≥13 years old. Only one vaccine-related...
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