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Sequence-specific binding by transcription factors (TFs) interprets regulatory information encoded in the genome. Using recently published universal protein binding microarray (PBM) data on the in vitro DNA binding preferences of these proteins for all possible 8-base-pair sequences, we examined the evolutionary conservation and enrichment within putative regulatory regions of the binding sequences...
Phemx (Pan hematopoietic expression) is a novel murine gene expressed in developmentally regulated sites of hematopoiesis from early in embryogenesis through adulthood. Phemx is expressed in hematopoietic progenitors and mature cells of the three main hematopoietic lineages. Conceptual translation of the murine Phemx cDNA predicts a 25-kDa polypeptide with four hydrophobic regions and several potential...
Gα q is the α subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase Cβ. We report the isolation and characterization of cDNA clones from a frontal cortex cDNA library encoding human Gα q . The encoded protein is 359 amino acids long and is identical in all but one amino acid residue to mouse Gα q . Analysis of human genomic DNA...
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