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In this paper, we propose a new consensus clustering algorithm, which is based on an existing clustering paradigm, called enhanced splitting merging awareness tactics (E-SMART). The problem of determining the number of clusters, which affects many state-of-theart consensus clustering algorithms, is addressed by the proposed CoCE-SMART algorithm. The idea behind CoCE-SMART is that SMART is used repeatedly...
Methamphetamine (METH) abuse is frequent in individuals infected with human immunodeficiency virus type-1 (HIV-1) and is suspected to aggravate HIV-associated neurocognitive disorders (HAND). METH is a psychostimulant that compromises several neurotransmitter systems and HIV proteins trigger neuronal injury but the combined effects of viral infection and METH abuse are incompletely understood. In...
The recently proposed UNCLES method has the ability to unify clustering results from multiple datasets under different types of external specifications. It can also tunably tighten the results such that many objects are unassigned from all of the clusters to obtain few tight clusters. Despite the success of this method, setting its parameters, such as the number of clusters (K) and the tuning parameters...
Although calcium phosphate-containing biomaterials are promising scaffolds for bone regenerative strategies, the osteoinductive capacity of such materials is poorly understood. In this study, we investigated whether endogenous mechanisms of in vivo calcium phosphate-driven, ectopic bone formation could be identified and used to induce enhanced differentiation in vitro of the same progenitor population...
PHOSPHO1 is a phosphoethanolamine/phosphocholine phosphatase that has previously been implicated in generating inorganic phosphate (Pi) for matrix mineralization. In this study, we have investigated PHOSPHO1 mRNA expression during embryonic development in the chick. Whole-mount in situ hybridization indicated that PHOSPHO1 expression occurred prior to E6.5 and was initially restricted to the bone...
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