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Estrogen deficiency is associated with the development of detrusor instability, irritative symptoms and urinary incontinence which may improve after estrogen therapy. Nitric oxide (NO) is a potent smooth muscle relaxant that can be produced as either a neurotransmitter or a paracrine agent within the urinary bladder. One of NO's mechanisms of action is the stimulation of cGMP production and the...
Background: In vivo study of bladder function has been limited to measurements of bladder pressure and intravesical volume without the capability for the assessment of the changes in bladder shape or size which ultimately reflects detrusor contractility and compliance.Aim: This study describes a new technique for in vivo assessment of bladder function using ultrasonic crystals placed in the bladder...
Estrogen deficiency is associated with the development of detrusor instability, irritative symptoms and urinary incontinence which may improve after estrogen therapy. Estrogen treatment increases the expression of NOS in several tissues. The similar identification of nitric oxide synthase (NOS) as a mediator for detrusor contractile activity could aid in our understanding of postmenopausal bladder...
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