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We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting...
Carbon materials are used in a diverse set of applications ranging from pharmaceuticals to catalysis. Nitrogen modification of carbon powders has shown to be an effective method for enhancing both surface and bulk properties of as‐received material for a number of applications. Unfortunately, control of the nitrogen modification process is challenging and can limit the effectiveness and reproducibility...
IL-36α, IL-36β and IL-36g are members of the IL-1 family of cytokines which bind to the IL-36R leading to recruitment of the IL-1 receptor accessory protein (IL-1RAcP) to initiate signal transduction. IL-36Ra is a natural antagonist of IL-36 and mutations in the IL-36Ra gene have been shown to be causative for a severe form of psoriasis, generalized pustular psoriasis. IL-36 is believed to initiate...
To characterize the role of rare complete human knockouts in autism spectrum disorders (ASDs), we identify genes with homozygous or compound heterozygous loss-of-function (LoF) variants (defined as nonsense and essential splice sites) from exome sequencing of 933 cases and 869 controls. We identify a 2-fold increase in complete knockouts of autosomal genes with low rates of LoF variation (≤5% frequency)...
Efforts in this paper seek to combine graph theory with adaptive dynamic programming (ADP) as a reinforcement learning (RL) framework to determine forward-in-time, real-time, approximate optimal controllers for distributed multi-agent systems with uncertain nonlinear dynamics. A decentralized continuous time-varying control strategy is proposed, using only local communication feedback from two-hop...
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