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The study of the genetics of diseases has been revolutionised by the advent of genome-wide genotyping technologies. Increasingly, genome-wide association studies are being used to identify positions within the human genome that have a link with a disease condition. These new data sets require the use of distributed resources, both for the statistical analysis and for the interpretation of the analysis...
The study of the genetic causes of disease is entering a new era. Variations in DNA sequence between individuals at a single position (locus) within the human genome are termed single nucleotide polymorphisms (SNPs), and may lead to a frank disease state or a variation in normal physiology. By comparing and contrasting the genomes of people who have a disease with the genomes of people who don't,...
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