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The interactions between the inflammatory mediators bradykinin, serotonin, prostaglandin E 2 and acid pH were studied in rat dorsal root ganglion neurons in culture. For this purpose, the cultures were stimulated by inflammatory mediators (bradykinin, serotonin, prostaglandin E 2 , 10 -5 M each) or acid solution (pH6.1) for 5min and the content of calcitonin gene-related...
The effects of capsaicin (CAPS; 30 nM, 300 nM, 3 μM) and acidic solutions (pH 6.6, 6.1, 5.6, 5.1) were studied in dorsal root ganglion (DRG) neurons from adult rats in short term culture using the whole cell patch-clamp technique and a system for fast drug application. At -60 mV holding potential, both CAPS 300 nM and 30 nM for 10 s did not induce a significant membrane current in pH 7.3. The first...
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