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Here we provide evidence that the cannabinoid agonist, Δ 9 -tetrahydrocannabinol (Δ 9 -THC) enhances quinine palatability and the CB 1 antagonist/inverse agonist, AM251, reduces sucrose and quinine palatability using the taste reactivity test, which provides a direct measure of palatability independently of appetitive behavior. In Experiment 1, rats were treated with a low...
The taste reactivity test was employed to determine the effect of pre-treatment with Δ 9 -Tetrahyrdrocannabinol THC on sucrose palatability. In Experiment 1, on each of 9 trials, rats were injected with THC or Vehicle prior to receiving a 5 min intraoral infusion of sucrose solution. The concentration of sucrose (2%, 10% or 32%) and the interval between the injection and the sucrose infusion...
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