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Rationale The purpose of this study was to evaluate the potential of oral combined cannabis constituents to reduce nausea. Objective The objective of this study was to determine the effect of combining subthreshold oral doses of Δ9-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea in rat models of conditioned gaping. Material and methods The potential of...
Rationale Δ9-Tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) found in cannabis both reduce the distressing symptom of nausea, but their combined effects are not understood. Objective The potential of combined doses of THC and CBDA to reduce acute nausea and anticipatory nausea in rodent models was assessed. Materials and methods For acute nausea, the potential of cannabinoid pretreatment(s)...
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