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Successful vaccination against any potential pathogen is critically dependant on inducing an appropriate immune response. The pivotal role of cytokines in the immune response to vaccination suggests that non-protective responses or responses that exacerbate disease subsequent to infectious challenge may be the result of limiting or preferential production of one or a number of these mediators. This...
This paper describes aspects of the safety and efficacy of recombinant ovine interleukin-1β (rovIL-1β) as an immunological adjuvant. A dose-response relationship was established using the intramuscular route, and significant adjuvant activity was observed following delivery of 10 or 100 μg of the cytokine delivered either in PBS or in combination with alum. Similar doses of rovIL-1β also showed...
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