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Currently, there is no effective strategy for the treatment of spinal cord injury (SCI). A combination of biomaterials and stem cell therapy seems to be a promising approach to increase regenerative potential after SCI. We evaluated the use of a cell-polymer construct based on a combination of the conditionally immortalized spinal progenitor cell line SPC-01_GFP3, derived from human fetal spinal cord...
Neural stem cells have considerable potential as therapeutic agents in their own right, but also as models of the pathophysiology of brain disease. We have used two approaches to generate human neural stem cells: conditional immortalisation, and somatic cell reprogramming (iPS cells). We have demonstrated that the conditionally-immortalised cells have efficacy in animal models of stroke and spinal...
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