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A study was conducted to determine whether changes in expected pain levels, desire for pain relief, or anxiety contribute to an increase in placebo analgesia over time as well as to determine whether placebo analgesic effects of IBS patients are related to endogenous opioid mechanisms. Twenty-six women with IBS were exposed to rectal stimulation (35 or 55mmHg for 30s) and tested under natural history...
The factors that contribute to the magnitude of placebo analgesia have, until recently, been elusive. This review explores the roles of external factors, such as conditioning, and experienced factors, such as expectation and desire for pain reduction, in placebo analgesia. Placebo analgesia effects have been found to reflect decreases in pain beyond that accounted for by the natural history of a pain...
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