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Osteopontin (OPN) is a non-collagenous extracellular matrix protein with pleiotropic functions, including mediation of cell adhesion and migration. Recently, high OPN serum levels were found in pancreatic ductal adenocarcinomas (PDACs) in which OPN mRNA was identified in macrophages. We investigated OPN expression at the protein level in 15 PDACs and 10 undifferentiated pancreatic carcinomas (UCs),...
Die undifferenzierten Karzinome des Pankreas sind selten. Sie sind anaplastische Varianten des duktalen Adenokarzinoms des Pankreas. Differenzialdiagnostisch müssen sie von Metastasen eines malignen Melanoms oder einer Sarkominfiltration immunhistochemisch abgegrenzt werden. Das undifferenzierte Pankreaskarzinom mit osteoklastären Riesenzellen ist eine besondere Variante, die auch in Assoziation mit...
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