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UbcH7 is an ubiquitin‐conjugating enzyme that interacts with parkin, an E3 ligase. The UbcH7–parkin complex promotes the ubiquitination and degradation of several proteins via the 26S proteasome. Cellular accumulation of the UbcH7–parkin targets alpha‐synuclein and synphilin‐1 has been associated with Parkinson disease. In mouse liver, 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin, an aryl hydrocarbon receptor...
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