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The present research is concerned with the mechanism investigation on the interaction between oxaliplatin and guanosine 5′-monophosphate (GMP) in the presence of glutathione (GSH). The binding modes of oxaliplatin with GMP and GSH were explored by HPLC and LC–MS techniques, respectively, in which four key intermediates were found and five adducts were determined in the reaction. The results indicated...
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