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APP 695 SWE/co+PS1/ΔE9 mice with Aβ plaques in neocortex and hippocampus were evaluated in tests of exploratory activity and spatial learning. On the initial testing day, 12-month-old APP 695 SWE/co+PS1/ΔE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without...
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