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Ein Pyren‐verknüpfter Proteinhohlraum zieht zwei Substratmoleküle an – ungefähr so wie der Duft einer Blume Schmetterlinge anlockt. A. Onoda, T. Hayashi und Mitarbeiter demonstrieren in ihrer Zuschrift auf S. 13806, dass eine polycyclische Pyrengruppe, die an das starre Proteingerüst der β‐Fass‐Struktur von Nitrobindin geknüpft ist, aromatische Wechselwirkungen mit einem Substrat bereitstellt. Eine...
A unique π‐expanded reaction cavity tethering a polycyclic moiety which provides a platform for substrate binding was constructed within the robust β‐barrel structure of nitrobindin (NB). NB variants with cavities of different sizes and shapes are coupled with N‐(1‐pyrenyl)maleimide (Pyr) to prepare a series of NB‐Pyr conjugates. The orientation of the pyrene moiety is fixed within the cavity by the...
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