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We examined whether following a hypoxic–ischemic insult in young animals there are long-lasting functional deficits that correlate either to histological tissue damage or to potential compensatory plasticity changes. Four-week-old rats were subjected to an episode of cerebral hypoxia–ischemia (right carotid artery occlusion + 30 min of hypoxia) or a sham operation. In hypoxic–ischemic animals there...
Hypoxic–ischemic changes in brain are detected earlier with diffusion-weighted (DW) than withT 2 -weighted magnetic resonance (MR) imaging techniques in adults, whereas the response in immature brain is not known. We investigated MR imaging changes prior to, during, and/or after 2 h of hypoxia–ischemia (right carotid artery occlusion+2 h of hypoxia) in 7-day-old rats anesthetized with isoflurane...
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