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Rationale: It is known that dopaminergic cell loss leads to increased endogenous cannabinoid levels and CB1 receptor density. Objective: The aim of this study was to evaluate the influence of dopaminergic cell loss, induced by injection of 6-hydroxydopamine, on the effects exerted by cannabinoid agonists on neuron activity in the subthalamic nucleus (STN) of anesthetized rats. Results: We have...
High levels of anandamide are located in the basal ganglia. The subthalamic nucleus (STN) is considered to be an important modulator of basal ganglia output. The present study aims at characterizing the modulation of the electrical activity of STN neurons by exogenous anandamide or endocannabinoids. Single‐unit extracellular recordings in anesthetized rats and patch‐clamp techniques in rat brain slices...
Activation of CB1 cannabinoid receptors in the basal ganglia interferes with movement regulation. The aim of this study was to characterize the effect of Δ9‐tetrahydrocannabinol (Δ9‐THC) on neurons in the subthalamic nucleus (STN) and to elucidate the mechanisms involved in this effect using single‐unit extracellular recordings in anesthetized rats. Administration of Δ9‐THC (0.25–2 mg/kg, i.v.) stimulated...
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