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We investigated contact system activation in red cell concentrate in mannitol-adenine-phosphate (MAP) solution (RC-MAP) during storage and leukocyte removal filtration. The contact system activation was assessed in terms of bradykinin (BK) generation. The BK level in the RC-MAP transiently but significantly (p<0.05) increased at 7 to 14 days of storage. Moreover, the BK level in 21-day-stored RC-MAP...
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