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Cell cycle progression is regulated by a wide variety of external factors, amongst them are growth factors and extracellular matrix factors. During the last decades evidence has been obtained that reactive oxygen species (ROS) may also play an important role in cell cycle progression. ROS may be generated by external and internal factors. In this overview we describe briefly the generation of ROS...
Several cellular signal transduction cascades are affected by oxidative stress. In this study, the effect of hydrogen peroxide (H 2 O 2 ) on the endocytosis of the epidermal growth factor (EGF) receptor was investigated. Exposure of HER14 cells to H 2 O 2 resulted in a concentration-dependent inhibition of EGF receptor internalization. Binding studies demonstrated that...
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